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NAD+ Novo 500mg
Original price was: € 60,00.€ 50,00Current price is: € 50,00.
Description
NAD+ (Nicotinamide adenine dinucleotide)
How does it work:
| Hallmark of Aging | Role of NAD+ | |
|---|---|---|
| Genomic instability | Adequate NAD+ availability is critical to drive DNA repair enzymes and pathways such as PARP1, SIRT1, and SIRT6 | |
| Cellular senescence | Low NAD+ promotes senescence in skin whilst restoration of NAD+ reduces the burden of senescent cells | |
| Epigenetic alterations | NAD+-dependent sirtuins are critical for youthful epigenetic regulation. Reduced NAD+ means sirtuins cannot perform this critical role | |
| Mitochondrial dysfunction | Adequate NAD+ is critical to healthy mitochondrial function and for the removal of damaged mitochondria | |
| Telomere attrition | NAD+ restoration is found to alleviate telomere dysfunction | |
| Altered intracellular communication | Low NAD+ promotes age-related inflammation | |
| Loss of proteostasis | NAD+ is required for SIRT1-mediated activation of autophagy to clear damaged cellular proteins | |
| Deregulated nutrient sensing | NAD+ levels are critical to sense the energetic status of the cell for adaptation to energy stress | |
| Stem cell exhaustion | NAD+ restoration leads to stem cell rejuvenation |
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